Disease link between hsa-let-7a and sarcoma.
miRNA ID (from miR2Disease)hsa-let-7a
Expressionnormal
MethodNorthern blot, qRT-PCR etc
DescriptionTranslocations involving HMGA2 and numerous translocation partners.These translocations generate a truncated HMGA2 mRNA lacking the let-7 complementary sites of the wild-type mRNA and are associated with the indicated tumors. In its 3'UTR, human HMGA2 has seven let-7 complementary sites, all of which are conserved in the mouse, rat, dog, and chicken.
Reference (Pubmed ID)17322030
Year2007
GenesHMGA2
CausalCausal
Plugin based on data from miR2Disease.