Disease link between hsa-let-7a and breast cancer.
miRNA ID (from miR2Disease)hsa-let-7a
Expressiondown-regulated
MethodNorthern blot, qRT-PCR etc
DescriptionIncreased let-7 paralleled reduced H-RAS and HMGA2, known let-7 targets. Silencing H-RAS in a breast tumor-initiating cells(BTIC)- enriched cell line reduced self renewal but had no effect on differentiation, while silencing HMGA2 enhanced differentiation but did not affect self renewal. Therefore let-7 regulates multiple BT-IC stem cell-like properties by silencing more than one target.
Reference (Pubmed ID)18083101
Year2007
GenesRAS, HMGA2
CausalCausal
Plugin based on data from miR2Disease.