Disease link between hsa-let-7a and lung cancer.
miRNA ID (from miR2Disease)hsa-let-7a
Expressiondown-regulated
MethodNorthern blot, qRT-PCR etc
DescriptionOverexpression of let-7 can inhibit lung tumor cell line growth.the expression of the RAS oncogene is regulated by let-7, and RAS is significantly overexpressed in lung tumor samples strongly implicate let-7 as a tumor suppressor in lung tissue and suggests a possible mechanism.
Reference (Pubmed ID)15766527
Year2005
GenesRAS
CausalCausal
Plugin based on data from miR2Disease.