Disease link between hsa-let-7a and lung cancer.
miRNA ID (from miR2Disease)hsa-let-7a-3
Expressionup-regulated
MethodNorthern blot, qRT-PCR etc
DescriptionThe let-7a-3's putative promoter region is heavily methylated by DNMT1 and DNMT3B in normal human tissues, but hypomethylated in lung adenocarcinomas. Let-7a-3┬Ęs promoter demethylation induced reactivation of the gene and increased proliferation in a lung cancer cell lines.
Reference (Pubmed ID)17308078
Year2007
Genesunknown
CausalCausal
Plugin based on data from miR2Disease.