Disease link between hsa-let-7a and non-small cell lung cancer (NSCLC).
miRNA ID (from miR2Disease)hsa-let-7a
Expressiondown-regulated
MethodNorthern blot, qRT-PCR etc
DescriptionA five-microRNA signature (let-7a, miR-221, miR-137, miR-372, and miR-182*) that is associated with survival and cancer relapse in NSCLC patients. This microRNA signature was validated by the testing set and an independent cohort. Patients with high-risk scores in their microRNA signatures had poor overall and disease-free survivals compared to the low-risk-score patients. This microRNA signature is an independent predictor of the cancer relapse and survival of NSCLC patients.promoted invasiveness of lung cancer cell lines.
Reference (Pubmed ID)18167339
Year2008
Genesunknown
CausalCausal
Plugin based on data from miR2Disease.