Disease link between hsa-let-7a and cholangiocarcinoma.
miRNA ID (from miR2Disease)hsa-let-7a
Expressionup-regulated
MethodNorthern blot, qRT-PCR etc
DescriptionmiRNA expression both in vitro and in vivo is altered by overexpression of IL-6; selective miRNAs including let-7a are up-regulated and contribute to the survival effects of enforced IL-6 activity; and let-7a contributes to the constitutively increased phosphorylation of Stat-3 by a mechanism involving the neurofibromatosis 2 (NF2) gene.
Reference (Pubmed ID)17220301
Year2007
GenesNF2
CausalCausal
Plugin based on data from miR2Disease.